Immunometabolic aspects of chronic nonspecific inflammation in obesity

Тhe disappointing results of epidemiological studies in recent years continue to attract the attention scientists obesity – one most acute medical and social problems our time. In last few decades, adipose tissue has been regarded as an immunobiological endocrine organ that secretes a large number hormones, adipokines growth factors play important role regulating energy homeostasis variety immune processes. The latest molecular genetic, immunometabolic, morphological microbiological force approach study this complex issue from different angles. One them is change work system conditions overweight, which based on formation chronic nonspecific inflammation. presented review examines pathogenetic mechanisms inflammatory process against background obesity, development several stages are currently conditionally distinguished: adipocyte hypertrophy, hypoxia, necrosis, cellular infiltration fibrosis. article also analyzes modern scientific data relationship inflammation with complications physiological characteristics child’s body, can be link metabolic disorders. addition, authors discuss possible connection various phenotypes violation implementation certain area there significant amount disagreement unresolved issues. Further key points underlying disorders disease.